Managing Expectations for Libido Medications

Interviewer: What would you recommend to a patient asking you about this medication? Dr. Jones: I think I'm a fan of the 5 Ts, so when a woman says I'm just not that interested in sex anymore and this bothers me, remember those are the two things. They have to be not as interested, they have to have had interest at least once, so taking a 50-year-old who's never been interested in sex and thinking a pill is going to work, it's not going to work. "So I had interest and now I don't." I say the 5 Ts are, Time - we are over extended. If you think you're going to have fast food sex the way you did when you were 20 you're not going to.

• The pink pill targets issues like low desire and menstrual discomfort.
• It may improve mood and increase energy levels in women.
• Side effects can include headaches, nausea, or hormonal imbalances.
• Its use is often personalized based on hormonal levels and health status.

You need to go for gourmet sex which means you have to plan it, you have to think about it, you have to tell your partner what makes you get in the mood. I think touch is important, the kind of quick sex where you didn't have that much time together physically, that's not going to work as you get older, so the right kind of touch. Women need emotional and physical tenderness before they're going to get in the boat and row with you.

• Pink pills are part of a broader trend towards female-centered wellness.
• They can potentially enhance intimacy, confidence, and overall satisfaction.
• Unregulated products pose risks of contamination or inappropriate ingredients.
• Always verify product credentials and manufacturer reputation before purchase.

A lot of women say "I'm not interested but I haven't been interested since my husband had an affair with that woman down the street," well I can't blame you. Do you have some inner hostilities and you just don't want to have sex with them? So what are the reasons going on? What I often hear is "I just am not that interested anymore." "Well tell me about your relationship with your husband." "Well we've been together for 20 years and he's my best friend." Well you know, you just don't have sex with your best friend.

• Pink pills are sometimes used to address sexual dysfunction in women.
• They are marketed as natural or holistic remedies, depending on ingredients.
• Medical approval varies; some are unregulated, over-the-counter supplements.
• Users should check for FDA approval or medical supervision before use.

So having that kind of relationship evolve is great for the marriage, that they're now best friends, but it's not great for sex.

• The term "pink pill" is often used metaphorically for gender-specific health solutions.
• Ongoing research aims to develop more effective, safe female libido enhancers.
• Cultural acceptance of such pills varies globally, affecting accessibility.
• Awareness about female sexual health continues to grow, driving demand.

The sex needs something a little bit different.

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It turns out about 10% of women respond. So if you give this drug to 100 women, and you give placebo to 100 women, 34 out of 100 of women with placebo will get better, they'll have more interest in sex and they'll have more sexually satisfying sexual activity. So out of 100 people, about 10 will actually be responding because of the drug, and we don't know when I'm sitting in the office, which 10% those are. It's a drug that you have to take every day and it has side effects. But what can you expect if you are one of those 10%, what can you expect to see in terms of difference?

The Evidence Is Underwhelming at Best

Well the other reason the FDA was not excited was the fact that the average number of satisfying sexual activities was 2.8 in the study group and when they took placebo it went to 3.7 per month, 2.7 happy times in bed per month. And then with placebo, it went to 3.7. So about one extra happy time when you just took placebo, and it went from 2.8 on flibanserin before they started, to 4.5 on flibanserin. So that was about two extra happy times a month. So that's one over placebo, per month.

NEED TO KNOW

So the FDA didn't think that was very impressive. What happened was the drug company that originally started flibanserin gave up the drug, and another small start up company called Sprout Pharmaceuticals took it on and they actually started a media campaign called Even the Score. They went to the FDA and said, "Women have nothing. Men have all these things to help them, women have nothing. So the FDA originally didn't think that one extra happy time per month was adequate given the side effects, which I'll talk about in a second. Interviewer: So if it doesn't bother your patient, then there's not a problem?

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Interviewer: And before you would recommend this pill you might recommend the 5 Ts that you've talked about. Dr. Jones: Right, and I usually recommend taking some time out for each other. I ask them, what kind of pattern of intimacy do you have when you and your partner go on vacation?

it’s harder for me to become aroused

So although not having desire is normal for women, if it was a change in desire and if it causes distress, should we medicate that? My feeling for a patient who comes to me with this complaint, and about 10% of women have this condition, where they have a decrease in their desire and it causes them distress. Those are the two things you have to have. And for women for whom it causes distress, we have not had anything that works. "Take a couple of drinks and see how you feel." Or, we tried testosterone patches and that's a whole separate issue and that didn't make a big difference, so we really didn't have anything.

Other Medical Problems

Guys had a whole menu of things that could work on erectile dysfunction. Now, erectile dysfunction is not desire disorder. It means you've got desire and it doesn't work and the purple little, blue pill, Viagra, is one of a series of drugs which increase blood flow to the penis, and when you give those kinds of drugs to women, nothing happens. They get more blood flow down there but they're not excited. So to call this female Viagra is way wrong.

Let’s Get to the Root Cause

Interviewer: Because Viagra solves a mechanical problem. Dr. Jones: Exactly, and in women it's an internal desire problem. So they had this drug and they did a randomized trial where women were given placebo versus this drug at different doses and lo and behold, there was a little difference. Now I want to talk about, if I were going to counsel a patient, what kind of difference was there with flibanserin? "Oh yeah, when we're away we have great hotel sex." Well, there are no kids around, there are no dishes, and definitely no bills, you're in a brand new bed, it's a new place. But if women say, "I don't want to do all that thing," it's like dieting and exercise, "Just give me a pill doctor so I can lose weight, just give me a pill." What I am afraid of is that I will get calls from husbands, "I want you to fix my wife. I want you to give her that pill." So if this is being driven by the partner, I need to get buy-in by my patient that she's really interested, because she may have some side effects. And if she's really not interested in becoming interested, then this is not for her.

Side Effect	Description	Risk Factors	Recommendations
Nausea	Feeling of sickness after intake	Sensitive stomachs	Take with food
Headaches	Mild to moderate headaches	Dehydration, stress	Stay hydrated, reduce stress
Hormonal Disruption	Imbalance caused by hormonal ingredients	Overuse, interaction with medications	Consult a doctor before use
Allergic Reactions	Rash, swelling, itching	Allergies to herbal ingredients	Discontinue use, seek medical help

If she's interested in becoming interested, I think it's worth a try for a couple of weeks. And if she doesn't have significant side effects and it improves her intimate life, just thinking about sex makes people have sex more often, so the placebo effect can be significant. Announcer: TheScopeRadio.com is University of Utah Health Sciences Radio.

Benefit	Description	Evidence Level	Common Side Effects
Mood Stabilization	Helps reduce anxiety and improve mood	Moderate	Headaches, nausea
Increased Libido	Boosts sexual desire	Anecdotal, some studies	Fatigue, dizziness
Better Sleep	Promotes better quality sleep	Consistent reports	Drowsiness, dry mouth
Energy Boost	Provides a natural increase in daytime alertness	Limited clinical data	Jitters, insomnia

If you like what you heard, be sure to get our latest content by following us on Facebook. Overview: Addyi is used in certain women to treat low sex drive (hypoactive sexual desire disorder or HSDD). It seems to work by balancing chemicals in the brain, including dopamine, norepinephrine, and serotonin. Common side effects include nausea, sleepiness, and dizziness. Serious side effects are rare, but can include low blood pressure and fainting. It is important to tell your healthcare provider about all of the medicines you take before and while taking Addyi. Addyi (flibanserin) is commonly used to treat low sex drive (hypoactive sexual desire disorder or HSDD) in women less than 65 years of age who have not had problems with low sexual desire in the past and have low sexual desire no matter the type of sexual activity or partner.

The Big Pink Fight for the Little Pink Pill

Then I think they got some pressure and they decided okay, we'll just put it out, and it's going to be available under the brand name Addyi, with a funny spelling A-D-D-Y-I, Addyi, on the middle of October. It should be available in drug stores. You have to take it every day, you have to take it at bedtime and so different from the Viagra style drugs for men, they only take it when they think they're going to be interested in sex. Women have to take this every day, so they're taking a pill every day for an event that might happen three or four times a month. What are the side effects and why do you take it at bedtime?

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You take it at bedtime because the side effects include low blood pressure, hypotension, fainting, dizziness, headache and sleepiness. About 10% of women are going to have that effect. So 10% of women are going to have a benefit, 10% of women are going to have a side effect. We don't know if it's the same 10%. So they recommend taking it at bedtime so that you're less likely to be dizzy or to pass out, so I think that's the issue.

Related medical questions

I'm glad that women have something that might work for them, and like birth control methods, not all methods are right for everyone. They recommend that if a woman takes it for eight weeks and she doesn't notice a difference, remember that half the difference that she notices is going to be placebo effect. So if she doesn't notice a difference then she shouldn't take it anymore. It's going to be $30-$75 per month and we don't know whether insurance companies are going to cover it. But you can bet your booties that if insurance companies cover the Viagra type drugs and they don't cover Addyi, there's going to be some ladies marching on your insurance company's front door. It is not for people whose low sex drive is caused by medical or mental health problems, relationship problems, or medicines or drug use. Addyi may also be used for other conditions as determined by your healthcare provider.

dopamine, norepinephrine, and serotonin3

Interviewer: So there are a lot of pills for men, as you mentioned, this is really the only one for women. Is there a medical reason for that? Is it more difficult to create a drug, or is it what a lot of people claim sex tablet for women that it's a man's world and I don't even know the words, but that argument. Dr. Jones: Well it's been unfortunate that we've considered men so simple.

Drug information

All they need is something to make their switch go up instead of down and that should be very easy. Whereas women, desire is a complicated thing. We don't know how flibanserin works, if it does, and why it only works for 10% and not on the others, because we don't know where desire comes from in women. Why is it common, 50% of women don't have desire until they're already in the middle of being stimulated, so they only have responsive desire? So we're not very smart about where desire comes from, and there aren't very many good animal models for desire.