1 INDICATIONS AND USAGE
Not to be taken more than once per day (2.1).CIALIS for once daily use:CIALIS may be taken without regard to food (2.5).DOSAGE FORMS AND STRENGTHSTablets: 5 mg, 10 mg, 20 mg (3).CONTRAINDICATIONSAdministration of CIALIS to patients using any form of organic nitrate is contraindicated.
7.3 Potential for CIALIS to Affect Other Drugs
Not to be taken more than once per day (2.1).CIALIS for once daily use:CIALIS may be taken without regard to food (2.5).DOSAGE FORMS AND STRENGTHSTablets: 5 mg, 10 mg, 20 mg (3).CONTRAINDICATIONSAdministration of CIALIS to patients using any form of organic nitrate is contraindicated. CIALIS was shown to potentiate the hypotensive effect of nitrates (4.1).History of known serious hypersensitivity reaction to CIALIS or ADCIRCA® (4.2).Administration with guanylate cyclase (GC) stimulators, such as riociguat (4.3).WARNINGS AND PRECAUTIONSPatients should not use CIALIS if sex is inadvisable due to cardiovascular status (5.1).Use of CIALIS with alpha-blockers, antihypertensives or substantial amounts of alcohol (≥5 units) may lead to hypotension (5.6, 5.9).CIALIS is not recommended in combination with alpha-blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. (2.7, 5.6, 7.1, 12.2)Patients should seek emergency treatment if an erection lasts >4 hours. Use CIALIS with caution in patients predisposed to priapism (5.3).Patients should stop CIALIS and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION). Patients with a "crowded" optic disc may also be at an increased risk of NAION (5.4, 6.2).Patients should stop CIALIS and seek prompt medical attention in the event of sudden decrease or loss of hearing (5.5).Prior to initiating treatment with CIALIS for BPH, consideration should be given to other urological conditions that may cause similar symptoms (5.14).ADVERSE REACTIONSMost common adverse reactions (≥2%) include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, and pain in limb (6.1).To report SUSPECTED ADVERSE REACTIONS, contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) or FDA at 1-800-FDA-1088 or INTERACTIONSCIALIS can potentiate the hypotensive effects of nitrates, alpha-blockers, antihypertensives or alcohol (7.1).CYP3A4 inhibitors (e.g.
12.1 Cialis Mechanism of Action
ketoconazole, ritonavir) increase CIALIS exposure (2.7, 5.10, 7.2) requiring dose adjustment: CIALIS for use as needed: no more than 10 mg every 72 hoursCIALIS for once daily use: dose not to exceed 2.5 mgCYP3A4 inducers (e.g. rifampin) decrease CIALIS exposure (7.2).USE IN SPECIFIC POPULATIONSHepatic Impairment (2.6, 5.8, 8.6):Mild or Moderate: Dosage adjustment may be needed.Severe: Use is not recommended.Renal Impairment (2.6, 5.7, 8.7):Patients with creatinine clearance 30 to 50 mL/min: Dosage adjustment may be needed.Patients with creatinine clearance less than 30 mL/min or on hemodialysis: For use as needed: Dose should not exceed 5 mg every 72 hours. Once daily use is not recommended.See 17 for PATIENT COUNSELING INFORMATION and FDA-approved patient labeling.Revised: 3/2026 CIALIS® is a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of: the signs and symptoms of benign prostatic hyperplasia (BPH) (1.2) ED and the signs and symptoms of BPH (ED/BPH) (1.3) If CIALIS is used with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks (1.4). Table of Contents FULL PRESCRIBING INFORMATION: CONTENTS*1 INDICATIONS AND USAGE1.1 Erectile Dysfunction1.2 Benign Prostatic Hyperplasia1.3 Erectile Dysfunction and Benign Prostatic Hyperplasia1.4 Limitation of Use2 DOSAGE AND ADMINISTRATION2.1 CIALIS for Use as Needed for Erectile Dysfunction2.2 CIALIS for Once Daily Use for Erectile Dysfunction2.3 CIALIS for Once Daily Use for Benign Prostatic Hyperplasia2.4 CIALIS for Once Daily Use for Erectile Dysfunction and Benign Prostatic Hyperplasia2.5 Use with Food2.6 Use in Specific Populations2.7 Concomitant Medications3 DOSAGE FORMS AND STRENGTHS4 CONTRAINDICATIONS4.1 Nitrates4.2 Hypersensitivity Reactions4.3 Concomitant Guanylate Cyclase (GC) Stimulators5 WARNINGS AND PRECAUTIONS5.1 Cardiovascular5.2 Potential for Drug Interactions When Taking CIALIS for Once Daily Use5.3 Prolonged Erection5.4 Effects on the Eye5.5 Sudden Hearing Loss5.6 Alpha-blockers and Antihypertensives5.7 Renal Impairment5.8 Hepatic Impairment5.9 Alcohol5.10 Concomitant Use of Potent Inhibitors of Cytochrome P450 3A4 (CYP3A4)5.11 Combination With Other PDE5 Inhibitors or Erectile Dysfunction Therapies5.12 Effects on Bleeding5.13 Counseling Patients About Sexually Transmitted Diseases5.14 Consideration of Other Urological Conditions Prior to Initiating Treatment for BPH6 ADVERSE REACTIONS6.1 Clinical Trials Experience6.2 Postmarketing Experience7 DRUG INTERACTIONS7.1 Potential for Pharmacodynamic Interactions with CIALIS7.2 Potential for Other Drugs to Affect CIALIS7.3 Potential for CIALIS to Affect Other Drugs8 USE IN SPECIFIC POPULATIONS8.1 Pregnancy8.2 Lactation8.3 Females and Males of Reproductive Potential8.4 Pediatric Use8.5 Geriatric Use8.6 Hepatic Impairment8.7 Renal Impairment10 OVERDOSAGE11 DESCRIPTION12 CLINICAL PHARMACOLOGY12.1 Mechanism of Action12.2 Pharmacodynamics12.3 Pharmacokinetics13 NONCLINICAL TOXICOLOGY13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility13.2 Animal Toxicology and/or Pharmacology14 CLINICAL STUDIES14.1 CIALIS for Use as Needed for ED14.2 CIALIS for Once Daily Use for ED14.3 CIALIS 5 mg for Once Daily Use for Benign Prostatic Hyperplasia (BPH)14.4 CIALIS 5 mg for Once Daily Use for ED and BPH16 HOW SUPPLIED/STORAGE AND HANDLING16.1 How Supplied16.2 Storage17 PATIENT COUNSELING INFORMATION17.1 Nitrates17.2 Guanylate Cyclase (GC) Stimulators17.3 Cardiovascular Considerations17.4 Concomitant Use with Drugs Which Lower Blood Pressure17.5 Potential for Drug Interactions When Taking CIALIS for Once Daily Use17.6 Priapism17.7 Sudden Loss of Vision17.8 Sudden Hearing Loss17.9 Alcohol17.10 Sexually Transmitted Disease17.11 Recommended Administration*Sections or subsections omitted from the full prescribing information are not listed. Sections or subsections omitted from the full prescribing information are not listed.
14.3 CIALIS 5 mg for Once Daily Use for Benign Prostatic Hyperplasia (BPH)
1 cialis canadian pharmacy no prescription INDICATIONS AND USAGE 1.2 Benign Prostatic HyperplasiaCIALIS is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).1.3 Erectile Dysfunction and Benign Prostatic HyperplasiaCIALIS is indicated for the treatment of ED and the signs and symptoms of BPH (ED/BPH).1.4 Limitation of UseIf CIALIS is used with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks because the incremental benefit of CIALIS decreases from 4 weeks until 26 weeks, and the incremental benefit of CIALIS beyond 26 weeks is unknown [see Clinical Studies (14.3)]. 2 DOSAGE AND ADMINISTRATION Do not split CIALIS tablets; entire dose should be taken.2.1 CIALIS for Use as Needed for Erectile DysfunctionThe recommended starting dose of CIALIS for use as needed in most patients is 10 mg, taken prior to anticipated sexual activity.The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once per day in most patients.CIALIS for use as needed was shown to improve erectile function compared to placebo up to 36 hours following dosing. Therefore, when advising patients on optimal use of CIALIS, this should be taken into consideration.2.2 CIALIS for Once Daily Use for Erectile DysfunctionThe recommended starting dose of CIALIS for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.The CIALIS dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability.2.3 CIALIS for Once Daily Use for Benign Prostatic HyperplasiaThe recommended dose of CIALIS for once daily use is 5 mg, taken at approximately the same time every day.When therapy for BPH is initiated with CIALIS and finasteride, the recommended dose of CIALIS for once daily use is 5 mg, taken at approximately the same time every day for up to 26 weeks.2.4 CIALIS for Once Daily Use for Erectile Dysfunction and Benign Prostatic HyperplasiaThe recommended dose of CIALIS for once daily use is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.2.6 Use in Specific PopulationsRenal ImpairmentCIALIS for Use as NeededCreatinine clearance 30 to 50 mL/min: A starting dose of 5 mg not more than once per day is recommended, and the maximum dose is 10 mg not more than once in every 48 hours.Creatinine clearance less than 30 mL/min or on hemodialysis: The maximum dose is 5 mg not more than once in every 72 hours [see Warnings and Precautions (5.7) and Use in Specific Populations (8.7)].CIALIS for Once Daily UseBenign Prostatic Hyperplasia and Erectile Dysfunction/Benign Prostatic HyperplasiaCreatinine clearance 30 to 50 mL/min: A starting dose of 2.5 mg is recommended. An increase to 5 mg may be considered based on individual response.Creatinine clearance less than 30 mL/min or on hemodialysis: CIALIS for once daily use is not recommended [see Warnings and Precautions (5.7) and Use in Specific Populations (8.7)].Hepatic ImpairmentCIALIS for Use as NeededMild or moderate (Child Pugh Class A or B): The dose should not exceed 10 mg once per day. CIALIS was shown to potentiate the hypotensive effect of nitrates (4.1).History of known serious hypersensitivity reaction to CIALIS or ADCIRCA® (4.2).Administration with guanylate cyclase (GC) stimulators, such as riociguat (4.3).WARNINGS AND PRECAUTIONSPatients should not use CIALIS if sex is inadvisable due to cardiovascular status (5.1).Use of CIALIS with alpha-blockers, antihypertensives or substantial amounts of alcohol (≥5 units) may lead to hypotension (5.6, 5.9).CIALIS is not recommended in combination with alpha-blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering.
| Attribute | Description | Notes |
|---|---|---|
| Generic Name | Tadalafil | Main active ingredient |
| Brand Name | Cialis (by Lilly) | Commercial name |
| Dosage Forms | Tablets, oral | Available forms |
| Typical Dose | 5 mg, 10 mg, 20 mg | Varies per prescription |
| Onset of Action | 30-60 minutes | Time to effect |
| Duration of Effect | Up to 36 hours | Pharmacological window |
(2.7, 5.6, 7.1, 12.2)Patients should seek emergency treatment if an erection lasts >4 hours.
| Study / Source | Effectiveness (%) | Comments |
|---|---|---|
| Clinical Trial 2022 | 70-80% | Used in men with ED |
| Patient Surveys | 75% | Reported satisfaction with Cialis |
| Comparative Studies | Slightly better than Viagra | Longer duration of effect |
| Real-world Data | 78% | Consistent effectiveness |
Use CIALIS with caution in patients predisposed to priapism (5.3).Patients should stop CIALIS and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION). Patients with a "crowded" optic disc may also be at an increased risk of NAION (5.4, 6.2).Patients should stop CIALIS and seek prompt medical attention in the event of sudden decrease or loss of hearing (5.5).Prior to initiating treatment with CIALIS for BPH, consideration should be given to other urological conditions that may cause similar symptoms (5.14).ADVERSE REACTIONSMost common adverse reactions (≥2%) include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, and pain in limb (6.1).To report SUSPECTED ADVERSE REACTIONS, contact Eli Lilly and Company at 1-800-LillyRx (1-800-545-5979) or FDA at 1-800-FDA-1088 or INTERACTIONSCIALIS can potentiate the hypotensive effects of nitrates, alpha-blockers, antihypertensives or alcohol (7.1).CYP3A4 inhibitors (e.g.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 5mg | 180 + 10 Pills | 159.65€ 152.05€ | |
| Cialis Generic | 10mg | 270 + 10 Pills | 308.71€ 294.01€ | |
| Cialis Professional | 20mg | 20 Pills | 78.33€ 74.60€ | |
| Cialis Original | 20mg | 34 + 2 Pills | 183.99€ 175.23€ | |
| Cialis Generic | 2.5mg | 10 Pills | 28.51€ 27.15€ | |
| Cialis Original | 20mg | 120 + 8 Pills | 497.29€ 473.61€ | |
| Cialis Black | 80mg | 60 + 4 Pills | 150.98€ 143.79€ | |
| Cialis Professional | 40mg | 30 Pills | 148.94€ 141.85€ | |
| Cialis Professional | 20mg | 180 + 4 Pills | 423.11€ 402.96€ | |
| Cialis Generic | 5mg | 90 + 6 Pills | 115.91€ 110.39€ | |
| Cialis Original | 20mg | 4 Pills | 41.99€ 39.99€ | |
| Cialis Generic | 60mg | 270 + 10 Pills | 443.96€ 422.82€ | |
| Cialis Soft Tabs | 20mg | 10 Pills | 39.03€ 37.17€ |
ketoconazole, ritonavir) increase CIALIS exposure (2.7, 5.10, 7.2) requiring dose adjustment: CIALIS for use as needed: no more than 10 mg every 72 hoursCIALIS for once daily use: dose not to exceed 2.5 mgCYP3A4 inducers (e.g. rifampin) decrease CIALIS exposure (7.2).USE IN SPECIFIC POPULATIONSHepatic Impairment (2.6, 5.8, 8.6):Mild or Moderate: Dosage adjustment may be needed.Severe: Use is not recommended.Renal Impairment (2.6, 5.7, 8.7):Patients with creatinine clearance 30 to 50 mL/min: Dosage adjustment may be needed.Patients with creatinine clearance less than 30 mL/min or on hemodialysis: For use as needed: Dose should not exceed 5 mg every 72 hours.
- Cialis is sometimes combined with psychological counseling for ED.
- Lifestyle factors, such as diet and exercise, can impact Cialis outcomes.
- Lilly supports research into ED causes and therapies.
- Psychological stress may reduce Cialis effectiveness.
- Cialis’s long half-life allows for flexible timing of dosages.
- Sexual partners may also benefit from understanding ED treatment.
- Proper storage prevents Cialis degradation and loss of potency.
- Research indicates Cialis may help vascular function overall.
- Patient confidentiality is maintained during Cialis prescription.
- Cialis is not a recreational drug; misuse can have health risks.
- Regular health checks recommended for chronic Cialis users.
- Patient testimonials often highlight increased quality of life.
Once daily use is not recommended.See 17 for PATIENT COUNSELING INFORMATION and FDA-approved patient labeling.Revised: 3/2026 CIALIS® is a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of: the signs and symptoms of benign prostatic hyperplasia (BPH) (1.2) ED and the signs and symptoms of BPH (ED/BPH) (1.3) If CIALIS is used with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks (1.4).
| Dosage | Recommended Patient Group | Notes |
|---|---|---|
| 10 mg daily | Adults with ED, as needed | 30 minutes before activity |
| 5 mg daily | Men with prostate symptoms | Once daily, at same time each day |
| 20 mg as needed | Occasional use, ED episodes | Max dose per 24 hours |
| Adjustments | Liver or kidney impairment | Lower doses recommended |
Table of Contents FULL PRESCRIBING INFORMATION: CONTENTS*1 INDICATIONS AND USAGE1.1 Erectile Dysfunction1.2 Benign Prostatic Hyperplasia1.3 Erectile Dysfunction and Benign Prostatic Hyperplasia1.4 Limitation of Use2 DOSAGE AND ADMINISTRATION2.1 CIALIS for Use as Needed for Erectile Dysfunction2.2 CIALIS for Once Daily Use for Erectile Dysfunction2.3 CIALIS for Once Daily Use for Benign Prostatic Hyperplasia2.4 CIALIS for Once Daily Use for Erectile Dysfunction and Benign Prostatic Hyperplasia2.5 Use with Food2.6 Use in Specific Populations2.7 Concomitant Medications3 DOSAGE FORMS AND STRENGTHS4 CONTRAINDICATIONS4.1 Nitrates4.2 Hypersensitivity Reactions4.3 Concomitant Guanylate Cyclase (GC) Stimulators5 WARNINGS AND PRECAUTIONS5.1 Cardiovascular5.2 Potential for Drug Interactions When Taking CIALIS for Once Daily Use5.3 Prolonged Erection5.4 Effects on the Eye5.5 Sudden Hearing Loss5.6 Alpha-blockers and Antihypertensives5.7 Renal Impairment5.8 Hepatic Impairment5.9 Alcohol5.10 Concomitant Use of Potent Inhibitors of Cytochrome P450 3A4 (CYP3A4)5.11 Combination With Other PDE5 Inhibitors or Erectile Dysfunction Therapies5.12 Effects on Bleeding5.13 Counseling Patients About Sexually Transmitted Diseases5.14 Consideration of Other Urological Conditions Prior to Initiating Treatment for BPH6 ADVERSE REACTIONS6.1 Clinical Trials Experience6.2 Postmarketing Experience7 DRUG INTERACTIONS7.1 Potential for Pharmacodynamic Interactions with CIALIS7.2 Potential for Other Drugs to Affect CIALIS7.3 Potential for CIALIS to Affect Other Drugs8 USE IN SPECIFIC POPULATIONS8.1 Pregnancy8.2 Lactation8.3 Females and Males of Reproductive Potential8.4 Pediatric Use8.5 Geriatric Use8.6 Hepatic Impairment8.7 Renal Impairment10 OVERDOSAGE11 DESCRIPTION12 CLINICAL PHARMACOLOGY12.1 Mechanism of Action12.2 Pharmacodynamics12.3 Pharmacokinetics13 NONCLINICAL TOXICOLOGY13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility13.2 Animal Toxicology and/or Pharmacology14 CLINICAL STUDIES14.1 CIALIS for Use as Needed for ED14.2 CIALIS for Once Daily Use for ED14.3 CIALIS 5 mg for Once Daily Use for Benign Prostatic Hyperplasia (BPH)14.4 CIALIS 5 mg for Once Daily Use for ED and BPH16 HOW SUPPLIED/STORAGE AND HANDLING16.1 How Supplied16.2 Storage17 PATIENT COUNSELING INFORMATION17.1 Nitrates17.2 Guanylate Cyclase (GC) Stimulators17.3 Cardiovascular Considerations17.4 Concomitant Use with Drugs Which Lower Blood Pressure17.5 Potential for Drug Interactions When Taking CIALIS for Once Daily Use17.6 Priapism17.7 Sudden Loss of Vision17.8 Sudden Hearing Loss17.9 Alcohol17.10 Sexually Transmitted Disease17.11 Recommended Administration*Sections or subsections omitted from the full prescribing information are not listed.
- Cialis’s indication for ED is supported by large-scale meta-analyses.
- Lilly recommends medical consultation before starting Cialis.
- Drug interactions include alpha-blockers and certain antifungals.
- Cialis should be used cautiously with other blood pressure medications.
- Common side effects include back pain and muscle aches.
- Rare side effects can include vision changes or hearing loss.
- Emergency medical help is needed if an erection lasts longer than 4 hours.
- Cialis improves blood flow by inhibiting phosphodiesterase type 5.
- Sexual stimulation is required for Cialis to be effective.
- Cialis is not addictive but should be used responsibly.
- The medication comes with usage instructions and warnings.
- Ongoing research explores new therapeutic uses for tadalafil.
Sections or subsections omitted from the full prescribing information are not listed.
13. Nonclinical Toxicology
14,000 cities
5.13 Counseling Patients About Sexually Transmitted Diseases
1 cialis canadian pharmacy no prescription INDICATIONS AND USAGE 1.2 Benign Prostatic HyperplasiaCIALIS is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).1.3 Erectile Dysfunction and Benign Prostatic HyperplasiaCIALIS is indicated for the treatment of ED and the signs and symptoms of BPH (ED/BPH).1.4 Limitation of UseIf CIALIS is used with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks because the incremental benefit of CIALIS decreases from 4 weeks until 26 weeks, and the incremental benefit of CIALIS beyond 26 weeks is unknown [see Clinical Studies (14.3)].
Highlights of Prescribing Information
2.6 Use in Specific Populations
5.5 Sudden Hearing Loss
2 DOSAGE AND ADMINISTRATION Do not split CIALIS tablets; entire dose should be taken.2.1 CIALIS for Use as Needed for Erectile DysfunctionThe recommended starting dose of CIALIS for use as needed in most patients is 10 mg, taken prior to anticipated sexual activity.The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once per day in most patients.CIALIS for use as needed was shown to improve erectile function compared to placebo up to 36 hours following dosing.
12.2 Pharmacodynamics
The use of CIALIS once per day has not been extensively evaluated in patients with hepatic impairment and therefore, caution is advised.Severe (Child Pugh Class C): The use of CIALIS is not recommended [see Warnings and Precautions (5.8) and Use in Specific Populations (8.6)].CIALIS for Once Daily UseMild or moderate (Child Pugh Class A or B): CIALIS for once daily use has not been extensively evaluated in patients with hepatic impairment. Therefore, caution is advised if CIALIS for once daily use is prescribed to these patients.Severe (Child Pugh Class C): The use of CIALIS is not recommended [see Warnings and Precautions (5.8) and Use in Specific Populations (8.6)].2.7 Concomitant MedicationsAlpha-BlockersED — When CIALIS is coadministered with an alpha-blocker in patients being treated for ED, patients should be stable on alpha-blocker therapy prior to initiating treatment, and CIALIS should be initiated at the lowest recommended dose [see Warnings and Precautions (5.6), Drug Interactions (7.1), and Clinical Pharmacology (12.2)].
17.1 Nitrates
5.12 Effects on Bleeding
Therefore, when advising patients on optimal use of CIALIS, this should be taken into consideration.2.2 CIALIS for Once Daily Use for Erectile DysfunctionThe recommended starting dose of CIALIS for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.The CIALIS dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability.2.3 CIALIS for Once Daily Use for Benign Prostatic HyperplasiaThe recommended dose of CIALIS for once daily use is 5 mg, taken at approximately the same time every day.When therapy for BPH is initiated with CIALIS and finasteride, the recommended dose of CIALIS for once daily use is 5 mg, taken at approximately the same time every day for up to 26 weeks.2.4 CIALIS for Once Daily Use for Erectile Dysfunction and Benign Prostatic HyperplasiaThe recommended dose of CIALIS for once daily use is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.2.6 Use in Specific PopulationsRenal ImpairmentCIALIS for Use as NeededCreatinine clearance 30 to 50 mL/min: A starting dose of 5 mg not more than once per day is recommended, and the maximum dose is 10 mg not more than once in every 48 hours.Creatinine clearance less than 30 mL/min or on hemodialysis: The maximum dose is 5 mg not more than once in every 72 hours [see Warnings and Precautions (5.7) and Use in Specific Populations (8.7)].CIALIS for Once Daily UseBenign Prostatic Hyperplasia and Erectile Dysfunction/Benign Prostatic HyperplasiaCreatinine clearance 30 to 50 mL/min: A starting dose of 2.5 mg is recommended.
5.10 Concomitant Use of Potent Inhibitors of Cytochrome P450 3A4 (CYP3A4)
An increase to 5 mg may be considered based on individual response.Creatinine clearance less than 30 mL/min or on hemodialysis: CIALIS for once daily use is not recommended [see Warnings and Precautions (5.7) and Use in Specific Populations (8.7)].Hepatic ImpairmentCIALIS for Use as NeededMild or moderate (Child Pugh Class A or B): The dose should not exceed 10 mg once per day.
- Cialis tablets come with different packaging, including blister packs and bottles.
- Eli Lilly provides comprehensive patient information leaflets with Cialis.
- Cialis is sometimes prescribed off-label for Raynaud’s phenomenon.
- The medication has a bioavailability of about 80%.
- Food intake has minimal impact on Cialis absorption.
- Cialis is metabolized primarily by the liver enzyme CYP3A4.
- Dose adjustments might be necessary for patients with kidney impairment.
- Cialis’s half-life is approximately 17.5 hours, contributing to long effect.
- Lilly has faced generic competition for Cialis in many markets.
- The drug’s patent expiration allowed entry of tadalafil generics.
- Cialis is included in some clinical guidelines for ED management.
- Monitoring for rare but serious side effects is part of patient care.
The use of CIALIS once per day has not been extensively evaluated in patients with hepatic impairment and therefore, caution is advised.Severe (Child Pugh Class C): The use of CIALIS is not recommended [see Warnings and Precautions (5.8) and Use in Specific Populations (8.6)].CIALIS for Once Daily UseMild or moderate (Child Pugh Class A or B): CIALIS for once daily use has not been extensively evaluated in patients with hepatic impairment.
Related/similar drugs
Therefore, caution is advised if CIALIS for once daily use is prescribed to these patients.Severe (Child Pugh Class C): The use of CIALIS is not recommended [see Warnings and Precautions (5.8) and Use in Specific Populations (8.6)].2.7 Concomitant MedicationsAlpha-BlockersED — When CIALIS is coadministered with an alpha-blocker in patients being treated for ED, patients should be stable on alpha-blocker therapy prior to initiating treatment, and CIALIS should be initiated at the lowest recommended dose [see Warnings and Precautions (5.6), Drug Interactions (7.1), and Clinical Pharmacology (12.2)].
- The Cialis patent expired in many countries by the mid-2020s.
- Generic tadalafil versions became widely accessible to patients.
- Market competition led to reduced prices for Cialis and generics.
- Lilly continues research on improved formulations of tadalafil.
- Online pharmacies sell Cialis; caution is advised to avoid counterfeits.
- The drug should only be purchased through licensed distributors.
- Awareness campaigns educate about safe use of Cialis.
- Side effect profiles remain similar between brand and generic versions.
- Pharmacovigilance monitors adverse events linked to Cialis use.
- Cialis remains an important option in ED treatment algorithms.
- The medication plays a role in men's sexual health discussions.
- Physicians frequently review Cialis use during follow-up visits.
